H6916
Macrophage Colony-Stimulating Factor human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Synonym(s):
MCSF
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About This Item
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 35-40 kDa (glycosylated)
Product Name
Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤4 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 35-40 kDa (glycosylated)
packaging
pkg of 10 μg
manufacturer/tradename
HumanZyme
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CSF1(1435)
General description
M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.
Biochem/physiol Actions
Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).
Physical form
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Analysis Note
The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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