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Merck
CN

H8885

Hydroxyzine dihydrochloride

≥97%

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About This Item

Empirical Formula (Hill Notation):
C21H27ClN2O2 · 2HCl
CAS Number:
2192-20-3
Molecular Weight:
447.83
NACRES:
NA.77
PubChem Substance ID:
24895830
UNSPSC Code:
12161501
EC Number:
218-586-3
MDL number:
MFCD00058200
Assay:
≥97%
Form:
powder
Quality level:
200

Key Documents

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Product Name

Hydroxyzine dihydrochloride, ≥97%

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

SMILES string

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

assay

≥97%

form

powder

solubility

H2O: soluble
alcohol: soluble
chloroform: soluble

Quality Level

200

Gene Information

human ... HRH1(3269)

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Application

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

General description

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT3136
BCBN6722V
BCBN5682V
BCBK8657V
BCBG7384V

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Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples
Rajendraprasad N, et al.
Chemical Industry Times / Hua Gong Shi Kan, 16(2), 127-132 (2010)
COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
Vitthal K R, et al.
International Journal of Current Research and Review, 4(24), 77-77 (2012)
Walter Ling et al.
Addiction (Abingdon, England), 107(2), 361-369 (2011-11-16)
To evaluate the efficacy and safety of the PROMETA™ Protocol for treating methamphetamine dependence. A double-blind, placebo-controlled 108-day study with random assignment to one of two study conditions: active medication with flumazenil (2 mg infusions on days 1, 2, 3
Mohammad Othman et al.
The Cochrane database of systematic reviews, 7(7), CD009223-CD009223 (2012-07-13)
Labour is a normal physiological process, but is usually associated with pain and discomfort. Numerous methods are used to relieve labour pain. These include pharmacological (e.g. epidural, opioids, inhaled analgesia) and non-pharmacological (e.g. hypnosis, acupuncture) methods of pain management. Non-opioid
E Davidovich et al.
The Journal of clinical pediatric dentistry, 36(4), 389-392 (2012-10-02)
To investigate whether behavior during hydroxyzine administration predicts children's behavior during dental treatment and whether behavior during treatment is affected by the complexity of treatment. 118 children aged 2 to 6.5 years old were treated under conscious sedation with oral
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