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Merck
CN

H8885

Sigma-Aldrich

Hydroxyzine dihydrochloride

≥97%

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About This Item

Empirical Formula (Hill Notation):
C21H27ClN2O2 · 2HCl
CAS Number:
2192-20-3
Molecular Weight:
447.83
EC Number:
218-586-3
MDL number:
MFCD00058200
UNSPSC Code:
12161501
PubChem Substance ID:
24895830
NACRES:
NA.77

Key Documents

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Quality Level

200

Assay

≥97%

form

powder

solubility

H2O: soluble
alcohol: soluble
chloroform: soluble

SMILES string

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

Application

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H336,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT3136
BCBN6722V
BCBN5682V
BCBK8657V
BCBG7384V

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COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
Vitthal K R, et al.
International Journal of Current Research and Review, 4(24), 77-77 (2012)
Walter Ling et al.
Addiction (Abingdon, England), 107(2), 361-369 (2011-11-16)
To evaluate the efficacy and safety of the PROMETA™ Protocol for treating methamphetamine dependence. A double-blind, placebo-controlled 108-day study with random assignment to one of two study conditions: active medication with flumazenil (2 mg infusions on days 1, 2, 3
Sp Georgopoulos et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 17(2), 377-382 (2012-06-29)
The purpose of the current experimental research was to investigate whether hydroxyzine can reduce the necrotic area in ischemia-reperfusion injury in epigastric rat skin flaps and to compare its role with cimetidine and vitamin C. From a total of 77
A Ghanizadeh
European review for medical and pharmacological sciences, 17(6), 839-841 (2013-04-24)
Bruxism or sleep jaw clenching and grinding of the teeth is an unresolved area in dentistry, psychiatry, and medicine. While many therapeutic approaches are introduced, nearly all of them are not effective or some of them are invasive approach. Three
E Davidovich et al.
The Journal of clinical pediatric dentistry, 36(4), 389-392 (2012-10-02)
To investigate whether behavior during hydroxyzine administration predicts children's behavior during dental treatment and whether behavior during treatment is affected by the complexity of treatment. 118 children aged 2 to 6.5 years old were treated under conscious sedation with oral
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Chromatograms

application for HPLC

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