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I0654

Interleukin-1 Soluble Receptor, Type I human

Name: Interleukin-1 Soluble Receptor, Type I human
Brand: SIGMA

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

(IL-1 sRI)

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD01323730

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Properties

biological source

human

Quality Segment

100

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

36 kDa

packaging

pkg of 0.1 mg

impurities

endotoxin, tested

UniProt accession no.

P14778

storage temp.

−20°C

Gene Information

human ... IL1R1(3554)

Description

General description

Interleukin-1 type 1 receptor (IL1R1) is a glycoprotein. It is mainly expressed on endothelial cells, epithelial cells, hepatocytes, fibroblasts, epidermal dendritic cells as well as T lymphocytes.

Biochem/physiol Actions

Interleukin-1 (IL-1), a cytokine, is a key regulator of acute and chronic inflammation. The IL-1 associated responses are achieved by association of IL-1 with IL-1 type 1 receptor (IL1R1).

Recombinant human IL-1 soluble receptor I is a transmembrane protein and a member of the immunoglobulin superfamily. It is expressed predominantly by T cells, fibroblasts, and endothelial cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-1β-dependent proliferation of a murine helper T cell line, D10.G4.1.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c