I0763
N9-Isopropylolomoucine
≥98% (HPLC)
Synonym(s):
2-(2′-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine
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About This Item
Empirical Formula (Hill Notation):
C17H22N6O
CAS Number:
Molecular Weight:
326.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C17H22N6O/c1-12(2)23-11-20-14-15(19-10-13-6-4-3-5-7-13)21-17(18-8-9-24)22-16(14)23/h3-7,11-12,24H,8-10H2,1-2H3,(H2,18,19,21,22)
SMILES string
CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12
InChI key
WHDJEAZLMYPLGL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage temp.
−20°C
Biochem/physiol Actions
Inhibitor of certain cyclin-dependent kinases; increased potency in some systems over olomoucine.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
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