I1029
Interleukin-2 Soluble Receptor γ human
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Synonym(s):
IL-2 sRγ
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About This Item
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
40 kDa
Impurities:
endotoxin, tested
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
1.979 μg/mL ED50
mol wt
40 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL2RG(3561)
General description
IL2RG (Interleukin-2 soluble receptor γ) is a type I transmembrane glycoprotein. It is a component of interleukin (IL)-receptors, including IL-2, IL-7, IL-9, IL-15 and IL-21.
Biochem/physiol Actions
IL2RG (Interleukin-2 soluble receptor γ) controls JAK3 (Janus kinase 3) signalling in ligand-dependent manner. Expression of IL2RG mRNA is upregulated in peripheral blood of humans suffering from schizophrenia. Mutations in IL2RG are associated with X-linked severe combined immunodeficiency, due to disturbances in function of cytokine receptors.
Recombinant human IL-2 soluble receptor γ is a member of the hematopoietin receptor family and is required for IL-2 receptor signaling.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Analysis Note
The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, MO7e, in the presence of 30 μg/ml of soluble IL-2 Rγ.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Hovsep Ghazaryan et al.
Psychiatry research, 217(3), 158-162 (2014-04-10)
Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokines together with their receptors associate with this disorder.
Taco W Kuijpers et al.
Haematologica, 98(7), 1030-1038 (2013-02-14)
Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause
A Agarwal et al.
Oncogene, 34(23), 2991-2999 (2014-08-12)
To understand the role of cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis, we designed a functional RNA interference (RNAi) screen targeting 188 cytokine and growth factor receptors that we found highly expressed in primary leukemia specimens. Using this
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