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I117

R(+)-IAA-94

Name: R(+)-IAA-94
Brand: SIGMA

≥98% (HPLC), chloride ion channel inhibitor, solid

Synonym(s):

Indanyloxyacetic acid 94, R(+)-Methylindazone, R(+)-[(6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)-oxy]acetic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈Cl₂O₄

CAS Number:

54197-31-8

Molecular Weight:

357.23

UNSPSC Code:

12352200

PubChem Substance ID:

24277844

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Product Name

R(+)-IAA-94, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +36.4°, c = 0.86 in methanol(lit.)

color

white

solubility

H₂O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble

storage temp.

2-8°C

SMILES string

C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3

InChI

1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1

InChI key

RNOJGTHBMJBOSP-QGZVFWFLSA-N

Description

Application

R(+)-IAA-94 has been used as a chloride ion channel inhibitor to study its effects on grepafloxacin uptake by human mononuclear (THP-1) cells . It has also been used as a chloride ion channel inhibitor to study its effects on moxifloxacin uptake by human mononuclear (THP-1) cells.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000530189

0000530187

0000494146

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Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

Michelle Batthish et al.

Cardiovascular research, 55(3), 660-671 (2002-08-06)

We have recently proposed that chloride (Cl(-)) channels contribute to ischemic preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we investigated the role of Cl(-) channels in pharmacological preconditioning. Isolated rabbit cardiomyocytes and isolated buffer-perfused rabbit hearts were

Influence of T-type Ca2+ (mibefradil) and Cl- (indanyloxyacetic acid 94) channel antagonists on ?1-adrenoceptor mediated contractions in rat aorta.

Duggan AJ and Tabrizchi R

Canadian Journal of Physiology and Pharmacology, 78(9), 714-720 (2000)

Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions

Hall I H, et al.

International Journal of Antimicrobial Agents, 22(6), 579-587 (2003)

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Global Trade Item Number

SKU	GTIN
I117-50MG-I	04061832574646
I117-250MG-I	04061832574639
I117-10MG-I	04061832574622