I1392
HA-100
Synonym(s):
1-(5-Isoquinolinesulfonyl)piperazine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C13H15N3O2S
CAS Number:
Molecular Weight:
277.34
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cl.O=S(=O)(N1CCNCC1)c2cccc3cnccc23
storage temp.
−20°C
Gene Information
human ... MYLK(4638), MYLK2(85366)
Biochem/physiol Actions
Inhibitor of PKA, PKC and myosin light chain kinase.
Analysis Note
Actual content given on the label
HCl content may vary.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J T O'Flaherty et al.
Biochemical and biophysical research communications, 163(3), 1456-1460 (1989-09-29)
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to
L Harvath et al.
Journal of immunology (Baltimore, Md. : 1950), 139(9), 3055-3061 (1987-11-01)
The protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine (C-I), inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol, without inhibiting superoxide release from PMN stimulated with the chemoattractants C5a or N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). In this study, we
D A Bass et al.
The Journal of biological chemistry, 262(14), 6643-6649 (1987-05-15)
Preincubation of neutrophils with certain agonists may "prime" the cells to cause increased responses to a second stimulus ("primed stimulation"). We used two approaches to examine the role of protein kinase C (Ca2+/phospholipid-dependent enzyme) in priming and stimulation by 1-oleoyl-2-acetylglycerol
S Daniels et al.
Comparative biochemistry and physiology. Comparative physiology, 105(4), 659-665 (1993-08-01)
1. The standard O2-paradox has been studied in the Langendorff-perfused rat heart. 2. Perfusion of glucose-free saline under anoxia did not cause release of creatine kinase (CK) although, it is suggested, there was a progressive rise in [Ca2+]i. 3. Ca(2+)-depletion
Regulation of neutrophil chemotaxis: correlations with actin polymerization.
L Harvath
Cancer investigation, 8(6), 651-654 (1990-01-01)
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