biological source
human
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
30-60 ng/mL ED50
mol wt
8.5 kDa
storage condition
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CCL1(6346)
Biochem/physiol Actions
I-309, a chemoattractant for monocytes but not neutrophils, is an approximately 8.5 kDa polypeptide of 73 amino acids. Human I-309 is thought to be a homolog of the mouse TCA3, and shows 42% amino acid homology to mouse TCA3.
I-309, a glycoprotein, is a chemoattractant for monocytes. It is secreted by monocytes, activated macrophages and T lymphocytes. Presence of I-309 in lymph node lymphatic sinuses controls metastases into the lymph nodes. It suppresses CCR8 (C-C motif chemokine receptor 8)-induced HIV (human immunodeficiency virus) infection and also participates in angiogenesis. I-309 is also referred to as CCL1 (C-C motif chemokine ligand 1).
Physical form
Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
Analysis Note
Bioactivity measured by ability of I-309 to chemoattract hCCR8 transfected BaF/3 cells.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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