I160
3-(1H-Imidazol-4-yl)propyl di(p-fluorophenyl)methyl ether hydrochloride
powder
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About This Item
Empirical Formula (Hill Notation):
C19H18F2N2O · HCl
Molecular Weight:
364.82
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C19H18F2N2O.ClH/c20-16-7-3-14(4-8-16)19(15-5-9-17(21)10-6-15)24-11-1-2-18-12-22-13-23-18;/h3-10,12-13,19H,1-2,11H2,(H,22,23);1H
SMILES string
Cl.Fc1ccc(cc1)C(OCCCc2c[nH]cn2)c3ccc(F)cc3
InChI key
LCHACRBDLUKTTM-UHFFFAOYSA-N
form
powder
color
pale gray
solubility
H2O: >4 mg/mL, methanol: 50 mg/mL, DMSO: 7 mg/mL
Gene Information
human ... HRH3(11255)
Biochem/physiol Actions
H3 histamine receptor antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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H Stark et al.
Die Pharmazie, 52(7), 495-500 (1997-07-01)
This study was performed in order to develop new leads for antagonists of the histamine H3-receptor subtype. omega-(1 H-Imidazol-4-yl)alkyl derivatives with ester, ketone or alcohol functionality in the side chain were synthesized and tested concerning their H3-receptor antagonist activity on
Novel histamine H3-receptor antagonists with benzyl ether structure or related moieties: Synthesis and structure-activity relationships.
Huls, A., et al.
Archives of Pharmacal Research, 329, 379-379 (1996)
Diphenylmethyl ethers: Synthesis and histamine H3-receptor antagonist in vitro and in vivo activity.
Huls, A., et al.
Bioorganic & Medicinal Chemistry Letters, 6, 2013-2018 (1996)
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