I17002
Interleukin-2 human
IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested
Synonym(s):
Interleukin-2 human, Interleukin-2, T-cell growth factor
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About This Item
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Recombinant:
expressed in HEK 293 cells
Mol wt:
15 kDa (glycosylated)
recombinant
expressed in HEK 293 cells
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤4 ng/mL ED50
mol wt
15 kDa (glycosylated)
technique(s)
cell culture | mammalian: suitable
suitability
endotoxin tested
storage temp.
−20°C
General description
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. It is a monomeric glycoprotein and proinflammatory cytokine, and contains four-a-helix bundles in its structure. IL-2 gene is mapped to human chromosome 4q27. Recombinant human IL-2 is expressed in human 293 cells as a glycoprotein with a calculated molecular mass of 15 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports better stability of the protein in culture.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a lymphokine that promotes the long-term proliferation of activated T cells and acts as an essential mediator of the immune response. IL-2 signals through the IL-2 receptor, majorly via the IL-2Ra subunit. IL-2 signaling via IL-2/anti-IL-2 immune complexes aids immune surveillance improvement during suppressed immunity. It also effectively controls infection. IL-2 plays a role in the activation and proliferation of natural killer (NK) cells, induces γ-inter-feron and B cell growth factor secretion and modulates the expression of the IL-2 receptor. It also elicits anti-tumor immunity. An elevated expression level of IL-2 along with other interleukins is observed in colorectal cancer.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Physical form
Supplied as a lyophilized powder containing phosphate buffered saline.
Analysis Note
The biological activity of recombinant human IL-2 was tested in culture by measuring its ability to stimulate proliferation of the mouse CTLL-2 cells (mouse cytotoxic T cell line).
Other Notes
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
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hcodes
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Hazard Classifications
Aquatic Chronic 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I17002-10UG | 04061833180716 |