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Merck
CN

I1759

Isosorbide dinitrate

powder

Synonym(s):

ISDN

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About This Item

Empirical Formula (Hill Notation):
C6H8N2O8
CAS Number:
87-33-2
Molecular Weight:
236.14
UNSPSC Code:
12352200
PubChem Substance ID:
24895946
MDL number:
MFCD00868238

Key Documents

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InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

SMILES string

[H][C@@]1([C@@]([H])(O[N+]([O-])=O)CO2)[C@@]2([H])[C@]([H])(O[N+]([O-])=O)CO1

InChI key

MOYKHGMNXAOIAT-UHFFFAOYSA-N

form

powder

contains

~60% lactose

color

white

solubility

organic solvents: soluble (alcohol, acetone and ether)

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Biochem/physiol Actions

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H207,H302

Hazard Classifications

Acute Tox. 4 Oral - Desen. Expl. 3

Storage Class

4.1A - Other explosive hazardous materials

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
105H0995
070H0488
043H1093
017H1006
016F05341

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S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this
C Sciorati et al.
British journal of pharmacology, 122(4), 687-697 (1998-01-10)
1. The role of nitric oxide (NO) in the control of cell growth is controversial since both stimulation and (more often) inhibition have been demonstrated in various cell types. In order to reinvestigate the problem and identify the sites of
Benjamin Medalion et al.
The Journal of thoracic and cardiovascular surgery, 150(3), 607-612 (2015-07-21)
Bilateral internal thoracic artery grafting in elderly patients is controversial. We compared the outcome of bilateral internal thoracic artery grafting with that of single internal thoracic artery and saphenous vein and radial artery conduits in these patients. Patients aged 70 years
C R Conti et al.
American heart journal, 110(1 Pt 2), 251-256 (1985-07-01)
The efficacy of isosorbide dinitrate (ISDN) in variant angina is enhanced by the addition of a calcium antagonist. A prospective double-blind, crossover trial of ISDN, 40 to 120 mg/day, and nifedipine, 40 to 120 mg/day, in 19 patients with variant
S Silber
European journal of clinical pharmacology, 38 Suppl 1, S35-S51 (1990-01-01)
Nitrates are highly effective both in terminating acute attacks of angina pectoris and in the prophylaxis of symptomatic and asymptomatic myocardial ischemia. Preload reduction by venodilatation is the prevailing mechanism of nitrates in patients with chronic stable angina and is
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