I2258
Insulin-Biotin labeled from bovine pancreas
lyophilized powder
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About This Item
UNSPSC Code:
12352204
MDL number:
form
lyophilized powder
composition
insulin, ~50% E1%/280
extent of labeling
~1 mol biotin per mol insulin
storage temp.
−20°C
Packaging
Package size based on insulin content
Physical form
Lyophilized powder containing sodium phosphate buffer salts
Preparation Note
Prepared from insulin, I 5500, coupled preferentially through one or both alpha amino groups via active ester to biotin at pH 6.0.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose.
P Cuatrecasas et al.
Biochemistry, 11(12), 2291-2299 (1972-06-06)
Nicolas J Pillon et al.
American journal of physiology. Endocrinology and metabolism, 309(1), E35-E44 (2015-05-07)
Obesity is associated with inflammation and immune cell recruitment to adipose tissue, muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also associated with tissue insulin resistance and can compromise insulin delivery to muscle. The muscle/fat microvascular endothelium
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