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Merck
CN

I2258

Sigma-Aldrich

Insulin-Biotin labeled from bovine pancreas

lyophilized powder

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About This Item

MDL number:
UNSPSC Code:
12352204
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form

lyophilized powder

composition

insulin, ~50% E1%/280

extent of labeling

~1 mol biotin per mol insulin

storage temp.

−20°C

Packaging

Package size based on insulin content

Physical form

Lyophilized powder containing sodium phosphate buffer salts

Preparation Note

Prepared from insulin, I 5500, coupled preferentially through one or both alpha amino groups via active ester to biotin at pH 6.0.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose.
P Cuatrecasas et al.
Biochemistry, 11(12), 2291-2299 (1972-06-06)
Nicolas J Pillon et al.
American journal of physiology. Endocrinology and metabolism, 309(1), E35-E44 (2015-05-07)
Obesity is associated with inflammation and immune cell recruitment to adipose tissue, muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also associated with tissue insulin resistance and can compromise insulin delivery to muscle. The muscle/fat microvascular endothelium

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