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Merck
CN

I2764

Sigma-Aldrich

ML-7

≥98% (TLC), myosin light chain kinase inhibitor, powder

Synonym(s):

1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H17IN2O2S · HCl
CAS Number:
110448-33-4
Molecular Weight:
452.74
MDL number:
MFCD00065524
UNSPSC Code:
12352200
PubChem Substance ID:
24278490
NACRES:
NA.77

Key Documents

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Product Name

ML-7, powder

Assay

≥98% (TLC)

Quality Level

200

form

powder

color

white

solubility

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI key

KDDALCDYHZIZMH-UHFFFAOYSA-N

Gene Information

human ... MYLK(4638), MYLK2(85366)

Application

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000453139
0000453139
0000396691
0000372007
0000309786

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Ziad Al Nabhani et al.
Inflammatory bowel diseases, 23(7), 1109-1119 (2017-05-19)
Crohn's disease (CD) pathogenesis is multifactorial involving genetic and environmental factors. Loss of function mutations in the nucleotide oligomerization domain 2 (NOD2) gene are the main genetic risk factor for CD. Like patients with CD, Nod2 mice are characterized by
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Sylvain Recoquillon et al.
Scientific reports, 7(1), 13664-13664 (2017-10-24)
Obstructive sleep apnea is characterized by intermittent hypoxia (IH) which alters endothelial function, induces inflammation and accelerates atherosclerosis-induced cardiovascular diseases. The non-muscular myosin light chain kinase (nmMLCK) isoform contributes to endothelial cell-cell junction opening. Deletion of nmMLCK protects mice from
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
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