Anti-Interleukin-18 Receptor antibody produced in goat

Interleukin 18 also refers as interferon-γ inducing factor (IGIF) is a proinflammatory cytokine produced on cell injury or trauma. It has a pivotal role in T cell helper type 1 (Th1) response to stimulate IFN-γ production in T cells and NK cells. Interleukin-18 Receptor (IL-18R) is a 60-110kD protein, expressed mainly in normal peripheral blood lymphocytes. IL-18R also expresses on T and B cell lineages and can activate NF-κB by recruiting IL-1 R-activating kinase (IRAK) and TNFR associated factor-6 (TRAF-6) which in turn activates NF-κB-inducing kinase (NIK). Anti-Interleukin-18 Receptor antibody can be used for neutralizing the biological activity of recombinant human IL-18 R. Goat anti-Interleukin-18 Receptor antibody reacts specifically with recombinant human IL-18 R. The product exhibits 5% cross-reactivity with recombinant mouse IL-18 R.

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Anti-Interleukin-18 Receptor antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml using human IL-18 R. It can also be used in indirect ELISA (working concentration:-0.5-1.0 μg/ml).

The antibody will neutralize the biological activity of human IL-18 receptor.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.