I4628
p-Iodo-DL-phenylalanine
Synonym(s):
2-Amino-3-(4-iodophenyl)propanoic acid
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About This Item
Empirical Formula (Hill Notation):
C9H10INO2
CAS Number:
Molecular Weight:
291.09
UNSPSC Code:
12352200
MDL number:
SMILES string
NC(Cc1ccc(I)cc1)C(O)=O
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D Hellwig et al.
Nuklearmedizin. Nuclear medicine, 47(5), 220-224 (2008-10-15)
Recently, p-[(123)I]iodo-L-phenylalanine (IPA) was clinically validated for brain tumour imaging. Preclinical studies demonstrated uptake of IPA into pancreatic adenocarcinoma suggesting its diagnostic application in patients with pancreatic tumours. The aim was to study the tumour uptake of IPA in patients
Ganesan Vaidyanathan et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(10), 1401-1406 (2011-05-31)
Radiolabeled amino acids have been used extensively in oncology both as diagnostic and therapeutic agents. In our pursuit to develop radiopharmaceuticals to target breast cancer, we were interested in determining the uptake of radioiodinated 4-iodophenylalanine, among other labeled amino acids
Phasing in iodine for structure determination.
Zbigniew Dauter
Nature biotechnology, 22(10), 1239-1240 (2004-10-08)
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination.
Jianming Xie et al.
Nature biotechnology, 22(10), 1297-1301 (2004-09-21)
A recently developed method makes it possible to genetically encode unnatural amino acids with diverse physical, chemical or biological properties in Escherichia coli and yeast. We now show that this technology can be used to efficiently and site-specifically incorporate p-iodo-L-phenylalanine
F A Verburg et al.
Nuklearmedizin. Nuclear medicine, 52(1), 36-42 (2013-01-11)
The objective of this study was to assess the feasibility, dosimetry, tolerability and efficacy of systemically administrated p-[(131)I]iodo-L-phenylalanine ((131)IPA) combined with hypo-fractionated external beam radiation therapy (EBRT) in patients with recurrent glioblastoma multiforme (GBM). Five patients (2 women, 3 men
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