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Merck
CN

I5514

D-myo-Inositol 1,4,5,6-tetrakis(phosphate) potassium salt

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About This Item

Linear Formula:
C6H8O18P4K8
CAS Number:
103497-71-8
Molecular Weight:
804.80
UNSPSC Code:
12352201
PubChem Substance ID:
329815385
MDL number:
MFCD02684406

Key Documents

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InChI

1S/C6H16O18P4.8K/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;;;;;/q;8*+1/p-8/t1-,2+,3-,4-,5+,6+;;;;;;;;/m1......../s1

SMILES string

[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O

InChI key

KOARMWMDZTZZSB-FPQWBLQBSA-F

storage temp.

−20°C

Biochem/physiol Actions

Component of lipid signaling pathway; shown to antagonize the negative regulation of calcium-mediated chloride secretion by epidermal growth factor; also shown to bind to pleckstrin homology (PH) domain of p130

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKBT4813V
MKBR8369V
MKBP8037V
SLBD6374V
SLBC8163V

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H Takeuchi et al.
The Biochemical journal, 318 ( Pt 2), 561-568 (1996-09-01)
We have previously identified a novel 130 kDa protein (p130) which binds Ins(1,4,5)P3 and shares 38% sequence identity with phospholipase C-delta 1 [Kanematsu, Misumi, Watanabe, Ozaki, Koga, Iwanaga, Ikehara and Hirata (1996) Biochem. J. 313, 319-325]. We have now transfected
S B Shears
Biochimica et biophysica acta, 1436(1-2), 49-67 (1998-12-05)
Cells from across the phylogenetic spectrum contain a variety of inositol phosphates. Many different functions have been ascribed to this group of compounds. However, it is remarkable how frequently several of these different inositol phosphates have been linked to various
L Eckmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(26), 14456-14460 (1998-02-07)
Several inositol-containing compounds play key roles in receptor-mediated cell signaling events. Here, we describe a function for a specific inositol polyphosphate, D-myo-inositol 1,4,5,6-tetrakisphosphate [Ins(1,4,5,6)P4], that is produced acutely in response to a receptor-independent process. Thus, infection of intestinal epithelial cells

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