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Merck
CN

I5514

Sigma-Aldrich

D-myo-Inositol 1,4,5,6-tetrakis(phosphate) potassium salt

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About This Item

Linear Formula:
C6H8O18P4K8
CAS Number:
103497-71-8
Molecular Weight:
804.80
MDL number:
MFCD02684406
UNSPSC Code:
12352201
PubChem Substance ID:
329815385

Key Documents

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storage temp.

−20°C

SMILES string

[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O

InChI

1S/C6H16O18P4.8K/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;;;;;/q;8*+1/p-8/t1-,2+,3-,4-,5+,6+;;;;;;;;/m1......../s1

InChI key

KOARMWMDZTZZSB-FPQWBLQBSA-F

Biochem/physiol Actions

Component of lipid signaling pathway; shown to antagonize the negative regulation of calcium-mediated chloride secretion by epidermal growth factor; also shown to bind to pleckstrin homology (PH) domain of p130

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBT4813V
MKBR8369V
MKBP8037V
SLBD6374V
SLBC8163V

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S B Shears
Biochimica et biophysica acta, 1436(1-2), 49-67 (1998-12-05)
Cells from across the phylogenetic spectrum contain a variety of inositol phosphates. Many different functions have been ascribed to this group of compounds. However, it is remarkable how frequently several of these different inositol phosphates have been linked to various
H Takeuchi et al.
The Biochemical journal, 318 ( Pt 2), 561-568 (1996-09-01)
We have previously identified a novel 130 kDa protein (p130) which binds Ins(1,4,5)P3 and shares 38% sequence identity with phospholipase C-delta 1 [Kanematsu, Misumi, Watanabe, Ozaki, Koga, Iwanaga, Ikehara and Hirata (1996) Biochem. J. 313, 319-325]. We have now transfected
L Eckmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(26), 14456-14460 (1998-02-07)
Several inositol-containing compounds play key roles in receptor-mediated cell signaling events. Here, we describe a function for a specific inositol polyphosphate, D-myo-inositol 1,4,5,6-tetrakisphosphate [Ins(1,4,5,6)P4], that is produced acutely in response to a receptor-independent process. Thus, infection of intestinal epithelial cells

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