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I5635

Monoclonal Anti-Human IgG2 antibody produced in mouse

Name: Monoclonal Anti-Human IgG2 antibody produced in mouse
Brand: SIGMA

clone HP-6014, ascites fluid

Synonym(s):

Monoclonal Anti-Human IgG2

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About This Item

NACRES:

NA.46

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

HP-6014, monoclonal

Application:

ELISA (i)

Citations:

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

secondary antibodies

clone

HP-6014, monoclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:5,000

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Related Categories

Protein Biology

Secondary Antibodies

Antibodies - Primary, Secondary & Recombinant Monoclonal

General description

Monoclonal Anti-Human IgG2 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Human IgG consists of four subclasses.

Application

Monoclonal Anti-Human IgG2 antibody has been used in in enzyme linked immunosorbent assay (ELISA) and in western blotting.
It may also be used:

in imprint immunofixation
in immunofluorometric assay
in hemagglutination
in hemagglutination inhibition
in particle counting immunoassay
in detection of cytoplasmic IgG

Biochem/physiol Actions

Anti-polysaccharide responses are mainly of the IgG2 sub-class while protein antigens give rise to IgG1 and IgG3 antibodies. Lipopolysaccharides stimulate an IgG2 response in peripheral blood leukocytes (PBL′s).

The antibody is specific for human IgG2 and is non-reactive with other IgG subclasses. This clone has been singled out as the most widely applicable IgG2 specific monoclonal antibody by the IUIS/WHO study.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

动物来源生物产品

This item has

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Certificates of Analysis (COA)

Lot/Batch Number

0000540028

0000439630

0000243304

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A conserved Leishmania hypothetical protein evaluated for the serodiagnosis of canine and human visceral and tegumentary leishmaniasis, as well as a serological marker for the posttreatment patient follow-up

Ribeiro P A, et al.

Diagnostic Microbiology and Infectious Disease, 92(3), 196-203 (2018)

Negative immunodiffusion test results obtained with sera of paracoccidioidomycosis patients may be related to low-avidity immunoglobulin G2 antibodies directed against carbohydrate epitopes

Neves AR, et al.

Clinical and Diagnostic Laboratory Immunology, 10(5), 802-807 (2003)

Identification of immune biomarkers related to disease progression and treatment efficacy in human visceral leishmaniasis

Portela A S B, et al.

Immunobiology, 223(3), 303-309 (2018)

Human anti-laminin 5 autoantibodies induce subepidermal blisters in an experimental human skin graft model.

Z Lazarova et al.

The Journal of investigative dermatology, 114(1), 178-184 (2000-01-05)

Patients with one form of cicatricial pemphigoid have IgG antibasement membrane autoantibodies against laminin 5 (alpha3beta3gamma2). Although passive transfer of rabbit anti-laminin 5 IgG to neonatal mice has been shown to induce subepidermal blisters that mimic those in patients, it

Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study.

Anna Babakhanyan et al.

Malaria journal, 14, 480-480 (2015-12-03)

Antibodies (Ab) to VAR2CSA prevent Plasmodium falciparum-infected erythrocytes from sequestrating in the placenta, i.e., prevent placental malaria (PM). The specificity of Ab to VAR2CSA associated with absence of PM is unknown. Accordingly, differences in the specificity of Ab to VAR2CSA

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Global Trade Item Number

SKU	GTIN
I5635-.5ML	04061833857533
I5635-.2ML	04061833857526

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