Immunobiology: The Immune System in Health and Disease, 5th ed.

The fifth edition is a major reorganization in which innate immune mechanisms that form the front line of host defense against infection occupy a new chapter at the beginning. Chapters describing antigen-receptors of B and T lymphocytes and generation of diversity in their antigen-binding regions have been reorganized to emphasize unifying concepts that apply to both B and T cell receptors. There is a single chapter on lymphocyte development that extends its unified approach to B and T cell development to a consideration of the survival and maturation of lymphocytes in peripheral lymphoid tissues. Discussion of T cell and B cell effector functions have been kept separate. CD-ROM included.