I6402
Anti-Interleukin-2 Soluble Receptor γ antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-IL-2 sRγ
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
UNSPSC Code:
51111800
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), Neutral, WB
Citations:
5
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: suitable, neutralization: suitable, western blot: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL2RG(3561)
General description
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 R which contains three membrane subunits: α, β and γ. The IL-2 R γ is also shared by IL-2, IL-4 and IL-7. The β and the γ subunits complex results in the binding of IL-2 with higher affinity. IL-2 R γ is expressed on monocytes, B cells, T cells, NK cells and neutrophils. IL-2 R activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Anti-Human IL-2 soluble receptor γ specifically reacts with IL-2 R γ. It does not show cross-reactivity with other cytokines.
Anti-Human IL-2 soluble receptor γ specifically reacts with IL-2 R γ. It does not show cross-reactivity with other cytokines.
Immunogen
recombinant human IL-2 soluble receptor β, expressed in Sf 21 insect cells.
Application
Anti-Human IL-2 soluble receptor (IL-2 sRγ) antibody may be used in immunoblotting at a working concentration of 1-2 μg/ml. For indirect ELISA, the recommended concentration is 0.5-1.0 μg/ml. By ELISA and immunoblotting the antibody shows < 2% cross-reactivity with recombinant human IL-3 sR α and IL-5 sR. The antibody is suitable for IL-2 sRγ neutralization assays.
Biochem/physiol Actions
The antibody shows ≤2% cross-reactivity with recombinant human IL-3 sRα and IL-5 sRβ.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Matthew A Williams et al.
Nature, 441(7095), 890-893 (2006-06-17)
Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth factor following in vitro activation, less is known about its role in shaping T-cell responses to acute infections in vivo. The use of IL-2- or IL-2-receptor-deficient mice is problematic
B H Nelson et al.
Advances in immunology, 70, 1-81 (1998-10-02)
Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the
Katrina K Hoyer et al.
Immunological reviews, 226, 19-28 (2009-01-24)
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the
Arian Laurence et al.
Immunity, 26(3), 371-381 (2007-03-17)
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory
Hans Dooms et al.
Journal of immunology (Baltimore, Md. : 1950), 172(10), 5973-5979 (2004-05-07)
The acquisition of long-term survival potential by activated T lymphocytes is essential to ensure the successful development of a memory population in the competitive environment of the lymphoid system. The factors that grant competitiveness for survival to primed T cells
Related Content
Datasheet
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service