I6534
III-63 hydrate
≥96% (HPLC), solid
Synonym(s):
WPE-III-63 hydrate
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About This Item
Empirical Formula (Hill Notation):
C60H80N8O9S · xH2O
CAS Number:
Molecular Weight:
1089.39 (anhydrous basis)
UNSPSC Code:
12352200
assay
≥96% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
III-63 is a (hydroxyethyl)urea γ-secretase inhibitor.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.
Anna Y Kornilova et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(9), 3230-3235 (2005-02-22)
gamma-Secretase is a structurally enigmatic multiprotein complex that catalyzes intramembrane proteolysis of a variety of substrates, including the amyloid beta-protein precursor of Alzheimer's disease and the Notch receptor essential to cell differentiation. The active site of this transmembrane aspartyl protease
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