I7160
IMS2186
≥98% (HPLC), solid
Synonym(s):
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
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About This Item
Empirical Formula (Hill Notation):
C18H16O4
CAS Number:
Molecular Weight:
296.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
SMILES string
COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
InChI
1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
InChI key
BZCADTHMZLYKAR-MDWZMJQESA-N
Biochem/physiol Actions
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
IMS2186 is an anti-proliferative and anti-angiogenic.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I7160-25MG | 04061832271934 |
| I7160-5MG | 04061833066096 |