I7388
Isoxanthopterin
≥97.5%, powder
Synonym(s):
2-Amino-4,7-dihydroxy-1,3,5,8-tetraazanaphthalene, 2-Amino-4,7-dihydroxypteridine, 2-Amino-4,7-pteridinediol
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About This Item
Empirical Formula (Hill Notation):
C6H5N5O2
CAS Number:
Molecular Weight:
179.14
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
208-469-5
Beilstein/REAXYS Number:
181594
MDL number:
assay
≥97.5%
form
powder
color
off-white
solubility
1 M NaOH: 50 mg/mL, clear, very dark yellow
storage temp.
room temp
SMILES string
NC1=NC2=C(N=CC(=O)N2)C(=O)N1
InChI
1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)
InChI key
GLKCOBIIZKYKFN-UHFFFAOYSA-N
Application
Isoxanthopterin is a substrate for the enzyme isoxanthopterin deaminase.
Other Notes
Product of xanthine oxidase oxidation of pterin, an enzyme involved in reactive oxygen formation.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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T Yamamoto et al.
Journal of chromatography. B, Biomedical applications, 681(2), 395-400 (1996-06-07)
An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector. The reaction mixture consists of 60 microliters of plasma and 240
I Ziegler
Journal of cellular biochemistry, 28(3), 197-206 (1985-01-01)
After iodine oxidation, biopterin, 6-hydroxymethylpterin, and 6-formylpterin were identified in mouse spleen lymphocytes by means of reverse-phase HPLC, Crithidia assay, and oxidative degradation. Concanavalin A activation induces a 30-fold increase in the pteridine amounts; biopterin as well as the sum
Gabriella Allegri et al.
Bioanalysis, 4(14), 1739-1746 (2012-08-11)
The present work describes an analytical method for urinary pterins by LC-MS/MS, with emphasis on the separation of 6- and 7-positional isomers of bio- and neopterins. Urine sample preparation consisted of oxidation by MnO(2), filtration and direct dilution in the