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I8132

scyllo-Inositol

Name: <I>scyllo</I>-Inositol
Brand: SIGMA

≥98%, Myo-inositol isomer

Synonym(s):

1,3,5/2,4,6-Hexahydroxycyclohexane, DTLET

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₂O₆

CAS Number:

488-59-5

Molecular Weight:

180.16

UNSPSC Code:

12352207

PubChem Substance ID:

24896132

NACRES:

NA.77

MDL number:

MFCD00065455

Assay:

≥98%

Quality level:

200

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Properties

Product Name

scyllo-Inositol, ≥98%

Quality Level

200

assay

≥98%

SMILES string

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3+,4+,5-,6-

InChI key

CDAISMWEOUEBRE-CDRYSYESSA-N

Description

Other Notes

Naturally occurring isomer of myo-inositol.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A bacterial cell factory converting glucose into scyllo-inositol, a therapeutic agent for Alzheimer's disease.

Christophe Michon et al.

Communications biology, 3(1), 93-93 (2020-03-04)

A rare stereoisomer of inositol, scyllo-inositol, is a therapeutic agent that has shown potential efficacy in preventing Alzheimer's disease. Mycobacterium tuberculosis ino1 encoding myo-inositol-1-phosphate (MI1P) synthase (MI1PS) was introduced into Bacillus subtilis to convert glucose-6-phosphate (G6P) into MI1P. We found that

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.

Aaron Y Lai et al.

Biochimica et biophysica acta, 1822(10), 1629-1637 (2012-07-18)

scyllo-Inositol (SI) is an endogenous inositol stereoisomer known to inhibit aggregation and fibril formation of the amyloid-beta peptide (Aβ). Human clinical trials using SI to treat Alzheimer disease (AD) patients have shown potential benefits. In light of the growing therapeutic

Amyloid-beta fibrillogenesis: structural insight and therapeutic intervention.

Kevin A Dasilva et al.

Experimental neurology, 223(2), 311-321 (2009-09-12)

Structural insight into the conformational changes associated with aggregation and assembly of fibrils has provided a number of targets for therapeutic intervention. Solid-state NMR, hydrogen/deuterium exchange and mutagenesis strategies have been used to probe the secondary and tertiary structure of

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Global Trade Item Number

SKU	GTIN
I8132-100MG	04061833621097
I8132-25MG	04061833630525
I8132-5MG	04061833630532