I8283
ICI 63,197
≥98% (HPLC)
Synonym(s):
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
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About This Item
Empirical Formula (Hill Notation):
C9H13N5O
CAS Number:
Molecular Weight:
207.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
248-383-5
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
mp
161.8-163 °C
solubility
DMSO: 13 mg/mL
storage temp.
2-8°C
SMILES string
CCCN1C(=O)C(C)=Cn2nc(N)nc12
InChI
1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
InChI key
UQDVRVNMIJAGRK-UHFFFAOYSA-N
Biochem/physiol Actions
Phosphodiesterase IV (PDE 4) inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M D Houslay
Cellular signalling, 2(1), 85-98 (1990-01-01)
Using experimentally derived data for the activities and kinetic constants of hepatocyte cyclic AMP phosphodiesterase isoenzymes together with the derived changes in adenylate cyclase activity, due to stimulation and subsequent desensitization by glucagon, a computer model was established to simulate
J Abrahamsen et al.
Pharmacology & toxicology, 76(3), 185-189 (1995-03-01)
The possible involvement of cyclic AMP in the stimulation-evoked 3H-overflow from rabbit isolated ear artery preloaded with 3H-noradrenaline was studied. Cyclic AMP (10(-5)-3 x 10(-4)M), 8-bromo-cyclic AMP (3 x 10(-4)M) and adenosine (10(-5)-3 x 10(-4)M) enhanced stimulation-evoked 3H-overflow. Dibutyryl-cyclic AMP
M R Mustafa et al.
European journal of pharmacology, 148(2), 171-177 (1988-03-29)
The effects of single and chronic doses of rolipram on the sensitivity of alpha 2-adrenoceptors have been compared with the phosphodiesterase inhibitors, isobutylmethylxanthine (IBMX) and ICI 63,197, and the antidepressant, desipramine. While pretreatment with a single dose of rolipram, ICI
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I8283-25MG | 04061833858547 |
| I8283-5MG | 04061832898155 |