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Merck
CN

I9890

Sigma-Aldrich

m-Iodobenzylguanidine hemisulfate salt

≥98% (HPLC and TLC), ADP ribosylation inhibitor

Synonym(s):

MIBG

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About This Item

Linear Formula:
C8H10IN3 · 1/2H2SO4
CAS Number:
87862-25-7
Molecular Weight:
324.13
MDL number:
MFCD00151189
UNSPSC Code:
12352200
PubChem Substance ID:
24278499
NACRES:
NA.77

Key Documents

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Product Name

m-Iodobenzylguanidine hemisulfate salt, ≥98% (HPLC and TLC)

Quality Level

200

Assay

≥98% (HPLC and TLC)

impurities

<0.5% Free iodobenzylamine

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NC(=N)NCc1cccc(I)c1.NC(=N)NCc2cccc(I)c2

InChI

1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)

InChI key

XNACDNPGABUBFR-UHFFFAOYSA-N

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Biochem/physiol Actions

Antitumor agent which inhibits ADP ribosylation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000480175
0000480175
0000439784
0000439784
0000417147

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Yunlong Zan et al.
Molecular imaging, 14, 373-384 (2015-07-15)
The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensive rat (SHR) model was
Sylvie Slaets et al.
International journal of geriatric psychiatry, 30(8), 864-869 (2014-11-05)
Iodine-123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart disease, heart failure, diabetes mellitus, arterial hypertension
L A Smets et al.
Cancer chemotherapy and pharmacology, 21(1), 9-13 (1988-01-01)
Meta-iodo-benzylguanidine (MIBG) is an analogue of the neurotransmitter norepinephrine. In its radioiodinated form, MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. The potential cytotoxicity of the unlabeled drug was tested. MIBG appeared
C Loesberg et al.
Biochimica et biophysica acta, 1037(1), 92-99 (1990-01-19)
Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabelled MIBG exerts several cell-biological effects, tentatively ascribed to interference with cellular
Yan Su et al.
International journal of molecular medicine, 34(3), 842-848 (2014-06-28)
The aim of the present study was to investigate the effects of meta-iodobenzylguanidine (MIBG) on the invasive properties of hepatocellular carcinoma (HCC) cells and examine whether these effects are due to the ability of MIBG to inhibit arginine-specific mono-ADP-ribosylation. Samples
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