J2753
JWH-133
solid
Synonym(s):
3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-THC, 3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-tetrahydrocannabinol
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About This Item
Empirical Formula (Hill Notation):
C22H32O
CAS Number:
Molecular Weight:
312.49
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
form
solid
drug control
USDEA Schedule I; Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
solubility
DMSO: <0.16 mg/mL, H2O: <0.28 mg/mL, ethanol: 11 mg/mL
storage temp.
−20°C
SMILES string
CCCC(C)(C)c1ccc2[C@@H]3CC(C)=CC[C@H]3C(C)(C)Oc2c1
Gene Information
human ... CNR2(1269)
mouse ... Cnr1(12801), Cnr2(12802)
Biochem/physiol Actions
Selective CB2 cannabinoid receptor agonist.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Weisi Fu et al.
Neuroscience letters, 595, 1-6 (2015-04-08)
Clinical trials investigating the analgesic efficacy of cannabinoids in multiple sclerosis have yielded mixed results, possibly due to psychotropic side effects mediated by cannabinoid CB1 receptors. We hypothesized that, a CB2-specific agonist (JWH-133) would decrease hyperalgesia in an experimental autoimmune
Jörg Reifart et al.
Transplantation, 99(1), 41-47 (2014-11-02)
CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the mechanisms of their migration in the postischemic liver remain unclear. We answered the questions of whether hepatic stellate cells (HSCs) interact with CD4+ T cells during
Tianshui Yu et al.
Histology and histopathology, 30(6), 737-749 (2015-01-16)
The aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in