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J4205

JK184

Name: JK184
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₈N₄OS

CAS Number:

315703-52-7

Molecular Weight:

350.44

UNSPSC Code:

51111800

PubChem Substance ID:

329815733

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

CCOc1ccc(Cc2nc(cs2)-c3c(C)nc4ccccn34)cc1

InChI

1S/C20H19N3OS/c1-3-24-16-9-7-15(8-10-16)12-19-22-17(13-25-19)20-14(2)21-18-6-4-5-11-23(18)20/h4-11,13H,3,12H2,1-2H3

InChI key

CBKFVRMNQUKWPX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

JK184 is a Hedgehog signaling pathway antagonist.

JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

100M4709

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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Helen O Oladapo et al.

Cancer letters, 411, 136-149 (2017-10-03)

Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing distinct

Global Trade Item Number

SKU	GTIN
J4205-5MG	04061833219294
J4205-25MG	04061832271965