J4705
Jatrorrhizine
from Tinospora sagittata, ≥95% (HPLC)
Synonym(s):
7,8,13,13α-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium, Neprotin, Yatrorizine
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About This Item
Empirical Formula (Hill Notation):
C20H20NO4
CAS Number:
Molecular Weight:
338.38
UNSPSC Code:
12352200
EC Number:
222-817-3
InChI key
MXTLAHSTUOXGQF-UHFFFAOYSA-O
InChI
1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
biological source
Tinospora sagittata
assay
≥95% (HPLC)
storage temp.
2-8°C
Biochem/physiol Actions
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Potential therapeutic for gastrointestinal disorders.
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Hong Lin Zhai et al.
Analytica chimica acta, 657(2), 131-135 (2009-12-17)
High-performance liquid chromatography (HPLC) fingerprint has been commonly used in the quality control and assessment of herbal medicines, and two-dimensional (2D) fingerprint obtained by means of HPLC-diode array detector (HPLC/DAD) can provide higher reliability. In this paper, an approach to
Fengqing Liu et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1006-1015 (2011-09-06)
Incurred rabbit plasmas samples were utilized for method quality assessment in this study, where an optimized protein precipitation method for the preparation of rabbit plasma samples and a rapid and sensitive liquid chromatography-electrospray ionization-mass spectrometry for the simultaneous determination of
Beibei Zhang et al.
The Journal of pharmacy and pharmacology, 64(3), 413-419 (2012-02-09)
Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata and Coptis chinensis, has been found to increase contractility of gastric antral and ileum smooth muscles
Hua-dong Zhu et al.
Journal of chromatography. A, 1218(34), 5867-5871 (2011-07-26)
This paper for the first time describes the development of micelle to solvent stacking (MSS) to nonaqueous capillary electrophoresis (NACE). In this proposed MSS-NACE, sodium dodecyl sulfate (SDS) micelles transport, release, and focus analytes from the sample solution to the
Rong Shi et al.
Biopharmaceutics & drug disposition, 33(3), 135-145 (2012-02-22)
Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as a natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to characterize its pharmacokinetics and metabolism. After intravenous administration, the plasma concentration kinetics
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