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Merck
CN

J4829

JFD00244

≥98% (HPLC), solid

Synonym(s):

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone

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About This Item

Empirical Formula (Hill Notation):
C30H26N2O4
CAS Number:
96969-83-4
Molecular Weight:
478.54
UNSPSC Code:
12352202
PubChem Substance ID:
329815737
MDL number:
MFCD00208443

Key Documents

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InChI

1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2

SMILES string

Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c4C(=O)c5ccccc5C(=O)c24)cc1

InChI key

UUJHFIBEJJLZBF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

violet

solubility

DMSO: ≥10 mg/mL, H2O: <2 mg/mL

storage temp.

room temp

Quality Level

100

Related Categories

Biochem/physiol Actions

JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
069K4612
127K4614

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Anu J Tervo et al.
Journal of medicinal chemistry, 49(24), 7239-7241 (2006-11-28)
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of these
Anu J Tervo et al.
Journal of medicinal chemistry, 47(25), 6292-6298 (2004-11-30)
Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of

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