K0253
Keratin from human epidermis
aqueous solution
Product Name
Keratin from human epidermis, aqueous solution
biological source
human epidermis
assay
≥90% (SDS-PAGE)
form
urea solution
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
human ... KRT1(3848)
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Application
Keratin from human epidermis has been used:
- as an analyte and a cross-reactant in the antibody-immobilized chip for testing selectivity coefficients
- as a standard in extracellular matrix (ECM) protein in in vitro protein degradation assays.
- asa a standard in enzyme linked immunosorbent assay (ELISA)
Biochem/physiol Actions
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.
General description
Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13. It is the primary component of hair, skin and nails.
Physical form
Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4
hcodes
signalword
Warning
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Keratin-based Biomaterials and Bioproducts, 5-5 (2017)
Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage
Jackson AS, et al.
American Journal of Respiratory and Critical Care Medicine, 175(3), 222-227 (2007)
A Pena et al.
Optics express, 13(17), 6667-6667 (2005-08-22)
We present corrected versions of the list of authors and of Section 2.1.
Christopher J Day et al.
PLoS neglected tropical diseases, 15(2), e0009136-e0009136 (2021-02-26)
Mycobacterium ulcerans is the causative agent of the chronic, necrotizing skin disease Buruli ulcer. Modes of transmission and molecular mechanisms involved in the establishment of M. ulcerans infections are poorly understood. Interactions with host glycans are often crucial in bacterial
Christian Mozet et al.
Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
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