K0629
Sodium 4-methyl-2-oxovalerate
leucine metabolite
Synonym(s):
α-Ketoisocaproic acid sodium salt, 4-Methyl-2-oxopentanoic acid sodium salt, 4-Methyl-2-oxovaleric acid sodium salt, Ketoleucine sodium salt
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About This Item
Linear Formula:
(CH3)2CHCH2COCOONa
CAS Number:
Molecular Weight:
152.12
UNSPSC Code:
12352107
NACRES:
NA.25
PubChem Substance ID:
EC Number:
224-816-3
Beilstein/REAXYS Number:
4239297
MDL number:
Quality Segment
assay
>98% (TLC)
form
powder
technique(s)
HPLC: suitable
color
white to off-white
mp
275 °C (dec.) (lit.)
application(s)
cell analysis
storage temp.
2-8°C
SMILES string
[Na+].CC(C)CC(=O)C([O-])=O
InChI
1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1
InChI key
IXFAZKRLPPMQEO-UHFFFAOYSA-M
Application
Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method.
Biochem/physiol Actions
α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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