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Merck
CN

K1513

Sigma-Aldrich

Kendomycin from Streptomyces violaceoruber

solid

Synonym(s):

(−)-TAN 2162

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About This Item

Empirical Formula (Hill Notation):
C29H42O6
CAS Number:
183202-73-5
Molecular Weight:
486.64
MDL number:
MFCD00076711
UNSPSC Code:
12352202
PubChem Substance ID:
24896208
NACRES:
NA.77

Key Documents

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form

solid

Quality Level

200

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
neoplastics

Mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(C)C(O)=O

InChI

1S/C32H61N13O9/c1-15(2)13-19(33)25(48)42-21(10-8-12-39-32(36)37)27(50)43-20(9-7-11-38-31(34)35)26(49)40-17(5)24(47)44-22(14-46)28(51)45-23(16(3)4)29(52)41-18(6)30(53)54/h15-23,46H,7-14,33H2,1-6H3,(H,40,49)(H,41,52)(H,42,48)(H,43,50)(H,44,47)(H,45,51)(H,53,54)(H4,34,35,38)(H4,36,37,39)

InChI key

PPBZOEOSJVJLRX-UHFFFAOYSA-N

General description

Chemical structure: peptide

Biochem/physiol Actions

Potent endothelin receptor antagonist. Antiosteoporotic compound. Shows also remarkable antibacterial and cytotoxic activity. A putative cellular target for cytotoxicity has been identified: inhibition or altered regulation of the proteasome.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
126K1423
096K1421
036K1231
125K1584
083K1073

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Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces. .
Zeeck, A. , and Bode, H.B.
Journal of the Chemical Society. Perkin Transactions 1, 323-323 (2000)

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