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Merck
CN

K1764

Kazusamycin A

from Streptomyces sp., ≥95% (HPLC), aqueous methanol solution

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About This Item

Empirical Formula (Hill Notation):
C33H48O7
CAS Number:
92090-94-3
Molecular Weight:
556.73
UNSPSC Code:
12352200
MDL number:
MFCD03265635

Key Documents

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SMILES string

CCC(\C=C\C1OC(=O)C=CC1C)=C/C(C)C\C=C\C(C)=C\C(CO)C(=O)C(C)C(O)C(C)C\C(C)=C\C(O)=O

biological source

Streptomyces sp.

assay

≥95% (HPLC)

form

aqueous methanol solution

solubility

methanol: water: soluble 7:3, DMSO: soluble, H2O: insoluble, chloroform: soluble, ethanol: soluble, hexane: insoluble, methanol: soluble

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

Kazusamycin A, an unsaturated branched chain fatty acid with a terminal lactone ring, is a hydroxy analog of Leptomycin B. It has significant in vitro cytotoxic activity against various human and mouse tumor lines encompassing a wide range of tissue types. Kazusamycin A exhibits in vivo antitumor activity against experimental murine tumors. It inhibits nuclear export and Rev translocation, a regulatory gene product in the HIV genome, at nanomolar concentrations.

Physical form

70% methanol solution.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

60.0 °F - closed cup

flash_point_c

15.56 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
035K4092

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The effect of kazusamycin on the growth of murine solid tumors and their spontaneous metastasis.
E Yoshida et al.
The Journal of antibiotics, 40(3), 391-393 (1987-03-01)
I Umezawa et al.
The Journal of antibiotics, 37(7), 706-711 (1984-07-01)
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity
M Sawamura
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 83(5), 627-635 (1992-05-01)
Kazusamycin A (KZMA) is a new anticancer antibiotic, which has been proven to have strong anticancer effect and several characteristic features different from currently available anticancer antibiotics. However, there has as yet been no report which had concerned itself with
Wang, Y., et al.
Helvetica Chimica Acta, 80, 2157-2167 (1997)
B J Roberts et al.
Cancer chemotherapy and pharmacology, 16(2), 95-101 (1986-01-01)
CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They are highly lipophilic acids characterized by unsaturated lactone and branched, polyunsaturated aliphatic side-chain moieties. All three agents demonstrated
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