K2139
K-252b solution
≥98% (HPLC), from Nonomuraea longicatena, ready-to-use solution
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About This Item
Empirical Formula (Hill Notation):
C26H19N3O5
CAS Number:
Molecular Weight:
453.45
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
SMILES string
[H][C@]1(C[C@]2(O)C(O)=O)O[C@]2(C)N3C4=C(C=CC=C4)C5=C3C(N1C6=C7C=CC=C6)=C7C8=C5CNC8=O
InChI key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
biological source
Nonomuraea longicatena
assay
≥98% (HPLC)
form
ready-to-use solution
concentration
1 mM in DMSO
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
Non-selective protein kinase inhibitor; ecto-protein kinase inhibitor; PKC inhibitor
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F
flash_point_c
87 °C
Regulatory Information
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S Fujii et al.
Neuroscience, 113(3), 617-628 (2002-08-02)
The mechanism of ATP-induced long-term potentiation (LTP) was studied pharmacologically using guinea-pig hippocampal slices. LTP, induced in CA1 neurons by 10 min application of 10 microM ATP, was blocked by co-application of the N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (5 or
Luis Cartuche et al.
Biomolecules, 10(4) (2020-04-30)
Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites of Trypanosoma and Leishmania genera that affect poor and remote populations in developing countries. These parasites share similar complex life cycles and modes of infection. It has been
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