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K2139

K-252b solution

Name: K-252b solution
Brand: SIGMA

≥98% (HPLC), from Nonomuraea longicatena, ready-to-use solution

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₁₉N₃O₅

CAS Number:

99570-78-2

Molecular Weight:

453.45

UNSPSC Code:

12352200

PubChem Substance ID:

329817133

MDL number:

MFCD27976629

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biological source

Nonomuraea longicatena

assay

≥98% (HPLC)

form

ready-to-use solution

concentration

1 mM in DMSO

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]1(C[C@]2(O)C(O)=O)O[C@]2(C)N3C4=C(C=CC=C4)C5=C3C(N1C6=C7C=CC=C6)=C7C8=C5CNC8=O

InChI

1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1

InChI key

AMSOPBXQXSAAAC-PLZPTFKGSA-N

Biochem/physiol Actions

Non-selective protein kinase inhibitor; ecto-protein kinase inhibitor; PKC inhibitor

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F

flash_point_c

87 °C

Regulatory Information

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Cooperativity between extracellular adenosine 5'-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons.

S Fujii et al.

Neuroscience, 113(3), 617-628 (2002-08-02)

The mechanism of ATP-induced long-term potentiation (LTP) was studied pharmacologically using guinea-pig hippocampal slices. LTP, induced in CA1 neurons by 10 min application of 10 microM ATP, was blocked by co-application of the N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (5 or

Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis.

Luis Cartuche et al.

Biomolecules, 10(4) (2020-04-30)

Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites of Trypanosoma and Leishmania genera that affect poor and remote populations in developing countries. These parasites share similar complex life cycles and modes of infection. It has been