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Merck
CN

K2769

Sigma-Aldrich

Monoclonal Anti-Keap1 antibody produced in mouse

~1.0 mg/mL, clone Keap1-2, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Cytosolic inhibitor of Nrf2, Anti-INrf2, Anti-Kelch-like ECH-associated protein 1

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

Keap1-2, monoclonal

form

buffered aqueous solution

mol wt

antigen ~69 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extract of human Jurkat cells

isotype

IgG1

UniProt accession no.

Q14145

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... KEAP1(9817)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
089K4807

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M Hussong et al.
Cell death & disease, 5, e1195-e1195 (2014-04-26)
The epigenetic sensor BRD4 (bromodomain protein 4) is a potent target for anti-cancer therapies. To study the transcriptional impact of BRD4 in cancer, we generated an expression signature of BRD4 knockdown cells and found oxidative stress response genes significantly enriched.
Jennifer Yinuo Cao et al.
Cell reports, 26(6), 1544-1556 (2019-02-07)
The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using genome-wide human haploid genetic screening technology coupled to fluorescence-activated
Jianglin Ma et al.
Molecular and cellular biology, 32(8), 1506-1517 (2012-02-15)
PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA). It controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppression. Here, we
Jiexiong Yao et al.
Inflammation, 42(2), 471-484 (2019-02-09)
Paraquat (PQ) intoxication seriously endangers human beings' health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes cell apoptosis, necrosis as well as ROS generation in a dose dependent

Related Content

Data Sheet - K2769

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