K3000
Kinetin riboside
proapoptotic anitproliferative plant growth regulator
Synonym(s):
6-Furfurylaminopurine riboside, N6-(2-Furanylmethyl)adenosine, N6-Furfuryladenosine
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About This Item
Empirical Formula (Hill Notation):
C15H17N5O5
CAS Number:
Molecular Weight:
347.33
NACRES:
NA.72
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
224-389-3
MDL number:
Assay:
≥98% (HPLC), ≥98% (TLC)
Form:
powder
Solubility:
acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
Storage temp.:
2-8°C
assay
≥98% (HPLC), ≥98% (TLC)
form
powder
solubility
acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23
InChI
1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
InChI key
CAGLGYNQQSIUGX-SDBHATRESA-N
Gene Information
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
General description
Kinetin riboside is a ribosylated form of kinetin. It is a natural cytokinin plant hormone.
Application
Kinetin riboside may be used:
- to study its cytotoxic effects on plant and animal tumor cells
- to investigate its apoptotic effects in both cancer and immortalized cells
- to elucidate its influence on human prostate cell epithelial-mesenchymal transition in vitro
Biochem/physiol Actions
Kinetin riboside exhibits cytotoxic and antiproliferative activities. In addition, it also shows anticancer activity by inducing apoptosis in various types of cancers including myeloid leukemia cells, mouse melanoma B16F-10 cells, and plant tumor cells.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Bo-Hwa Choi et al.
Cancer letters, 261(1), 37-45 (2007-12-29)
Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while
Michael Webb et al.
Bioorganic & medicinal chemistry letters, 29(11), 1270-1277 (2019-04-08)
Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression regulators such as PPAR or AMPK, (2) using antioxidant compounds
Zhenfang Cheng et al.
Journal of separation science, 41(11), 2386-2392 (2018-02-24)
In this work, an easy, effective, and sensitive method based on graphene oxide@silica@magnetite composites as adsorbent of magnetic solid-phase extraction combined with liquid chromatography and tandem mass spectrometry, was established and validated for the trace analysis of cytokinins in different
Global Trade Item Number
| SKU | GTIN |
|---|---|
| K3000-5G | 04061833868393 |
| K3000-100G | 04061833697900 |