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K3627

Kallikrein from porcine pancreas

≥40 units/mg protein

Synonym(s):

Kininogenase, Kininogenin

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About This Item

CAS Number:
9001-01-8
EC Number:
3.4.21.35 (BRENDA, IUBMB)
UNSPSC Code:
12352204
EC Number:
232-574-5
NACRES:
NA.54
MDL number:
MFCD00131428
Specific activity:
≥40 units/mg protein
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form

solid

Quality Segment

specific activity

≥40 units/mg protein

storage temp.

2-8°C

General description

Kallikrein exists as an inactive prokallikrein in the porcine pancreas. The porcine kallikrein gene region is localized on chromosome 6q12-q21.

Application

Kallikrein from porcine pancreas has been used:
  • as a matrix metalloproteinase-9 (MMP-9) zymogen activator
  • as a component of cell culture to test its effect on rat subventricular zone (SVZ) cells and oligodendrocyte progenitor cells (OPC) proliferation and survival
  • as a model enzyme to track kinetic data and visual detection limits of hydrolysis by hydrolytic enzymes in the two-phases array

Biochem/physiol Actions

Kallikrein active forms are generated by the enzymatic action of trypsin. It is a serine protease that mediates the activation of growth factors and substrates.

Other Notes

One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.

Signal Word

Danger

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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