Skip to Content
Merck
CN

Key Documents

View All Documentation

K3768

PYK2 (360-690), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

CADTK, CAKB, FADK2, FAK2, PKB, PTK, PTK2B, RAFTK

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

NACRES:
NA.32
UNSPSC Code:
12352202
Specific activity:
216-292 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

216-292 nmol/min·mg

mol wt

~39 kDa

UniProt accession no.

Q14289

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTK2B(2185)

General description

PYK2 (proline-rich tyrosine kinase 2, also known as FAK2/RAFTK) belongs to the focal adhesion PTK (protein tyrosine kinase) family. It is activated by signals that increases intracellular calcium concentration and also by stress signals. PYK2 is present in the endothelium, central nervous system, and hematopoietic lineages.

Biochem/physiol Actions

In osteoclasts, PYK2 (proline-rich tyrosine kinase 2) might be a crucial mediator of integrin αvβ3 signaling events that affects osteoclast physiology as well as pathology. It has a tumor-promoting role in multiple myeloma.

Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

常规特殊物品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLBZ5199
SLBN8903V
SLBN5618V
SLBN1071V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Wen-Cheng Xiong et al.
Frontiers in bioscience : a journal and virtual library, 8, d1219-d1226 (2003-09-06)
Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases
H Avraham et al.
Cellular signalling, 12(3), 123-133 (2000-03-08)
Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activation and tyrosine phosphorylation of protein tyrosine kinases (PTKs). Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and tyrosine kinases, is
Yu Zhang et al.
Blood, 124(17), 2675-2686 (2014-09-14)
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that

Global Trade Item Number

SKUGTIN
K3768-10UG04061837755996

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service