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Merck
CN

K4019

KHS101

≥98% (HPLC)

Synonym(s):

N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

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About This Item

Empirical Formula (Hill Notation):
C18H21N5S
CAS Number:
1262770-73-9
Molecular Weight:
339.46
NACRES:
NA.77
PubChem Substance ID:
329817142
UNSPSC Code:
12352200
MDL number:
MFCD18206916

Key Documents

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InChI key

DGRJOOOHPBSAHD-UHFFFAOYSA-N

SMILES string

CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1

InChI

1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

KHS101 is a small molecule differentiator of neuronal differentiation: TACC3 binder.
KHS101 is a small molecule that drives neuronal differentiation of hippocampal neuronal progenitor cells (NPC). Treatment of NPCs with KHS101 induces expression of the neurogenic transcription factor NeuroD and the neuronal marker Tuj1, and exhibit neuronal morphology and spiking activity (EC50 1 uM). KHS101 binds tightly to TACC3, which is a structural component of the centrosome and mitotic spindle apparatus. TACC3 loss of function studies in mice and stem cells suggest that TACC3 controls progenitor cell expansion and terminal differentiation during development.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Julia Petschnigg et al.
Journal of molecular biology, 429(2), 280-294 (2016-12-14)
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) that-once activated upon ligand binding-leads to receptor dimerization, recruitment of protein complexes, and activation of multiple signaling cascades. The EGFR is frequently overexpressed or mutated in various cancers

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