K4394
PKF118-310
≥98% (HPLC)
Synonym(s):
1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, Toxoflavin, Xanthothricin
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About This Item
Empirical Formula (Hill Notation):
C7H7N5O2
CAS Number:
Molecular Weight:
193.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1N=CN=C(C1=N2)C(N(C)C2=O)=O
InChI
1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
InChI key
SLGRAIAQIAUZAQ-UHFFFAOYSA-N
Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
PKF118-310 is a Tcf4/b-catenin antagonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Articles
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Giulia Devescovi et al.
Applied and environmental microbiology, 73(15), 4950-4958 (2007-06-15)
Burkholderia glumae is an emerging rice pathogen in several areas around the world. Closely related Burkholderia species are important opportunistic human pathogens for specific groups of patients, such as patients with cystic fibrosis and patients with chronic granulomatous disease. Here
Z Wang et al.
British journal of pharmacology, 117(2), 293-298 (1996-01-01)
1. It has been suggested that the toxic effect of toxoflavin (TXF) produced by Pseudomonas cocovenenas is mainly due to the impairment of electron transfer of the mitochondrial respiratory chain. However, the cardiovascular effect of TXF is unknown. In the
Yongsung Kang et al.
Scientific reports, 9(1), 11038-11038 (2019-08-01)
The activated methyl cycle (AMC) is responsible for the generation of S-adenosylmethionine (SAM), which is a substrate of N-acylhomoserine lactone (AHL) synthases. However, it is unknown whether AHL-mediated quorum sensing (QS) plays a role in the metabolic flux of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| K4394-5MG | 04061833944721 |
| K4394-25MG | 04061832924472 |