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Molecular Biology

Assay

>99% (SDS-PAGE)

form

buffered aqueous solution

specific activity

77,000 U/mg

concentration

2,000 U/mL

shipped in

dry ice

storage temp.

−20°C

General description

Uracil-DNA Glycosylase catalyzes the hydrolysis of the N-glycosylic bond between the uracil and sugar, leaving an abasic site in uracil-containing single or double-stranded DNA. The enzyme shows no measurable activity on short oligonucleotides (<6 bases), or RNA substrates.

Application

Suitable for:
  • Removing uracil from DNA
  • Control of carry-over contamination in PCR

Features and Benefits

  • Ultra-purification process for ultimate enzyme performance
  • Highest quality specifications for ultimate product consistency
  • Undetectable DNA and nuclease contamination

Physical form

Supplied in 10 mM Tris-HCl, 50 mM NaCl, 1 mM DTT, 0.1 mM EDTA, and 50% glycerol at pH 7.5 @ 25° C

Other Notes

1 unit is defined as the amount of enzyme that catalyzes the release of 1.8 nmol of Uracil in 30 minutes from double-stranded, tritiated, Uracil containing-DNA at 37° C in 1X UDG Reaction Buffer.
Source of protein: A recombinant E. coli strain carrying the Uracil DNA Glycosylase gene from E. coli K-12.
Supplied with:KEM0001B (10X UDG Reaction Buffer)
Unit Size: 10,000 U

Storage Class Code

10 - Combustible liquids


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