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Merck
CN

L1915

Lq2

>98% (HPLC), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

ChTx2

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About This Item

UNSPSC Code:
12352200
MDL number:
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recombinant

expressed in E. coli

assay

>98% (HPLC)

form

lyophilized powder

mol wt

4359 Da

storage temp.

−20°C

Biochem/physiol Actions

ROMK1 inward rectifier potassium channel blocker; also blocks single K(Ca) channels in planar lipid bilayer (rat muscle); Lq2 action is on the extracellular side of the pore.


Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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K Lucchesi et al.
The Journal of membrane biology, 109(3), 269-281 (1989-08-01)
Two charybdotoxin peptides were purified from venom of the Israeli scorpion, Leiurus quinquestriatus hebraeus. Microsequencing of the most abundant toxin, ChTX-Lq1, revealed identity with the 37-residue peptide previously sequenced by Gimenez-Gallego et al. [Gimenez-Gallego, G., et al., Proc. Natl. Acad.
Z Lu et al.
Biochemistry, 36(23), 6936-6940 (1997-06-10)
We have purified a protein inhibitor of an inward-rectifier K+ channel, ROMK1, from the venom of the scorpion Leiurus quinquestriatus var. hebraeus. The inhibitor is Lq2, a previously discovered blocker of voltage- and Ca2+-activated K+ channels. Mutations were made on