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Merck
CN

L2776

Lys-Gln-Ala-Gly-Asp-Val

≥97% (HPLC)

Synonym(s):

KQAGDV

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About This Item

Empirical Formula (Hill Notation):
C25H44N8O10
CAS Number:
80755-87-9
Molecular Weight:
616.66
UNSPSC Code:
12352200
PubChem Substance ID:
24896326
MDL number:
MFCD00133515

Key Documents

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InChI

1S/C25H44N8O10/c1-12(2)20(25(42)43)33-24(41)16(10-19(36)37)31-18(35)11-29-21(38)13(3)30-23(40)15(7-8-17(28)34)32-22(39)14(27)6-4-5-9-26/h12-16,20H,4-11,26-27H2,1-3H3,(H2,28,34)(H,29,38)(H,30,40)(H,31,35)(H,32,39)(H,33,41)(H,36,37)(H,42,43)

SMILES string

CC(C)C(NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(O)=O

InChI key

AFAFFVKJJYBBTC-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

technique(s)

LC/MS: suitable

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is a cell adhesion peptide used to study adhesion of platelets to neutrophils via the integrin glycoproteins gpIIb/IIIa.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBV3127
SLBT3038
SLBC6231V
SLBB5147V
071M1914V

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T K Gartner et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 198(1), 649-655 (1991-10-01)
Antiplatelet agents are clinically useful as antithrombotic entities. The importance of antiplatelet agents led us to design, synthesize, and characterize a new antiplatelet peptide. This peptide is a presumptive mimic of a ligand binding site on the platelet fibrinogen receptor.
Brenda K Mann et al.
Journal of biomedical materials research, 60(1), 86-93 (2002-02-09)
The effects of cell adhesion peptides (RGDS, KQAGDV, VAPG) on vascular smooth muscle cells grown on modified surfaces and in tissue-engineering scaffolds were examined. Cells were more strongly adhered to surfaces modified with adhesive ligands than to control surfaces (no
Bernard Chabannes et al.
British journal of haematology, 121(2), 341-348 (2003-04-16)
Polymorphonuclear leucocytes and blood platelets co-operate in several pathophysiological processes, and arachidonic acid (AA) metabolites produced in response to the activation of these cells are potent mediators of their functions. We studied the role of platelets in the formation of
Integrins.
E Ruoslahti
The Journal of clinical investigation, 87(1), 1-5 (1991-01-01)
Roy R Hantgan et al.
Protein science : a publication of the Protein Society, 15(8), 1893-1906 (2006-08-01)
This study tested the hypothesis that high-affinity binding of macromolecular ligands to the alphaIIbbeta3 integrin is tightly coupled to binding-site remodeling, an induced-fit process that shifts a conformational equilibrium from a resting toward an open receptor. Interactions between alphaIIbbeta3 and
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