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Merck
CN

L4886

Leukotriene C4

≥92.5% (HPLC), 45-70 μg/mL in methanol

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About This Item

Empirical Formula (Hill Notation):
C30H47N3O9S
CAS Number:
72025-60-6
Molecular Weight:
625.77
UNSPSC Code:
12352200
PubChem Substance ID:
24896380
EC Number:
200-659-6
MDL number:
MFCD00151079

Key Documents

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InChI key

GWNVDXQDILPJIG-KVUXNHQJSA-N

InChI

1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6+,10-9+,12-11+,16-13+

SMILES string

OC(CCCC(O)=O)C(SCC(NC(CCC(C(O)=O)N)=O)C(NCC(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCCC

assay

≥92.5% (HPLC)

concentration

45-70 μg/mL in methanol

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

Leukotriene formed from the conjugation of LTA4 with glutathione. Induces bronchoconstriction and renal vasoconstriction.

Packaging

Packaged under argon.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBD0048V
SLBD0048
071M1411
061M1888
011M1293

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Donald W Macglashan et al.
The Journal of allergy and clinical immunology, 132(4), 906-911 (2013-06-25)
Treatment of allergic patients with omalizumab results in a paradoxical increase in their basophil histamine release (HR) response ex vivo to cross-linking anti-IgE antibody. It is not known whether this change in response is associated with an increase in intrinsic cellular
Rikiya Koketsu et al.
International archives of allergy and immunology, 161 Suppl 2, 23-31 (2013-06-05)
Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can
Gabriele Jedlitschky et al.
Vitamins and hormones, 64, 153-184 (2002-03-20)
Transport proteins control the release of the endogenous glutathione conjugate leukotriene C4 (LTC4) from leukotriene-synthesizing cells as well as its hepatobiliary and renal elimination. The photolabile conjugated triene structure of LTC4 has enabled direct photoaffinity labeling of the multidrug resistance
Evan S Dellon et al.
The American journal of gastroenterology, 107(10), 1503-1511 (2012-07-11)
Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap. We aimed to determine whether staining for tissue biomarkers would differentiate EoE from GERD, suggesting utility for diagnosis of EoE. In this case-control study, EoE patients defined by consensus
B Samuelsson
Science (New York, N.Y.), 220(4597), 568-575 (1983-05-06)
Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can
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