L5045
Luotonin B
≥98%
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About This Item
Empirical Formula (Hill Notation):
C18H11N3O2
CAS Number:
Molecular Weight:
301.30
NACRES:
NA.77
UNSPSC Code:
12352202
biological source
synthetic (organic)
assay
≥98%
form
solid
solubility
chloroform/methanol (4:1): 2 mg/mL, clear to slightly hazy, colorless to yellow
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TOP1(7150)
General description
Luotonin B is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and E, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. It is an oxidation product of Luotonin A and is converted to Luotonin E by methanol treatment.
Biochem/physiol Actions
Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
Preparation Note
Solubility is tested at 2 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Recent advances in the studies on luotonins
Liang JL, et al.
Molecules (Basel), 16(6), 4861-4883 (2011)
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