L5756
Lithocholic acid 3-sulfate disodium salt hydrate
Synonym(s):
3α-Hydroxy-5β-cholan-24-oic acid 3-sulfate, Sulfolithocholic acid
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About This Item
Empirical Formula (Hill Notation):
C24H38Na2O6S · xH2O
CAS Number:
Molecular Weight:
500.60 (anhydrous basis)
UNSPSC Code:
12161900
PubChem Substance ID:
MDL number:
SMILES string
[Na+].[Na+].[H]O[H].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](C2)OS([O-])(=O)=O
assay
≥95% (TLC)
storage temp.
−20°C
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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N P Dorvil et al.
The American journal of clinical nutrition, 37(2), 221-232 (1983-02-01)
The hypothesis that the amino acid used for the conjugation of sulfolithocholate (S-LCA) is a critical determinant of its cholestatic potential was tested in the guinea pig which conjugates 90% of its bile acids with glycine. Twelve groups of animals
Serum-sulfated lithocholate as an indicator of cholestasis during parenteral nutrition in infants and children.
M K Farrell et al.
JPEN. Journal of parenteral and enteral nutrition, 6(1), 30-33 (1982-01-01)
H Takikawa et al.
Biochimica et biophysica acta, 1004(2), 147-150 (1989-08-08)
Biliary excretion and biotransformation of tracer doses of [14C]lithocholic acid and its sulfate and glucuronide intravenously injected into bile-drainaged rats were compared. Biliary excretion efficiency was in the order of unconjugate sulfate glucuronide and all conjugates were completely excreted into
Lithocholate sulphation in the baboon.
M J Dew et al.
Journal of medical primatology, 11(1), 59-64 (1982-01-01)
H Takikawa et al.
Digestive diseases and sciences, 43(1), 188-192 (1998-03-21)
Biliary excretion of lithocholate-3-sulfate and ursodeoxycholate 3,7-disulfate is markedly impaired in EHBR. In the present study, the effects of ursodeoxycholate 3,7-disulfate infusion on lithocholate-3-sulfate excretion were studied in EHBR and Sprague-Dawley rats. Although in control rats, ursodeoxycholate 3,7-disulfate infusion had
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