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Merck
CN

L5908

Sigma-Aldrich

Lacto-N-fucopentaose I

from human milk, ≥90% (HPAE/PAD)

Synonym(s):

α-L-Fuc (1→2)-β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc, LNFP I

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About This Item

Empirical Formula (Hill Notation):
C32H55NO25
CAS Number:
7578-25-8
Molecular Weight:
853.77
MDL number:
MFCD00679119
UNSPSC Code:
12352201
PubChem Substance ID:
24896424

Key Documents

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biological source

human milk

Assay

≥90% (HPAE/PAD)

storage temp.

2-8°C

SMILES string

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@H]3[C@H](O)[C@@H](CO)O[C@@H](O[C@H]4[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)[C@@H]4O)[C@@H]3NC(C)=O)[C@@H](O)[C@H](O)[C@@H]1O

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Other Notes

Blood group H-active pentasaccharide.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
122K3787
079H3873
076H3869
113K0620

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Andrew Almond et al.
Biochemistry, 43(19), 5853-5863 (2004-05-12)
Fucosylated O- and N-linked glycans are essential recognition molecules in plants and animals. To understand how they impart their functions, through interactions with proteins, requires a detailed analysis of structure and dynamics, but this is presently lacking. In this study
T Yamagata et al.
Biochemical and biophysical research communications, 181(3), 1004-1009 (1991-12-31)
Mouse embryos at implantation stage were stained successfully with lacto-N-fucopentaose I (LNF-I) bearing neoglycoprotein labeled with rhodamine synthesized by us for the first time. The fluorescent neoglycoproteins carrying LNF-II, -III, LND-I, or LNT failed to stain the embryos. The embryo
S Lindenberg et al.
Journal of reproduction and fertility, 83(1), 149-158 (1988-05-01)
Seven oligosaccharides isolated from human milk were tested for their effect in an in-vitro model of mouse blastocyst adhesion and trophoblast outgrowth on endometrial epithelial monolayers. One compound, lacto-N-fucopentaose I (LNF I), produced a significant reduction in the percentage of
S J Kimber et al.
Journal of reproduction and fertility, 89(1), 13-21 (1990-05-01)
Ovariectomy and hormone replacement of mice were used to examine the hormonal control of expression on the uterine surface of a carbohydrate determinant (lacto-N-fucopentaose I, LNF I), involved in the initial interaction between the blastocyst and the endometrial epithelium at
S Lindenberg
Danish medical bulletin, 38(5), 371-380 (1991-10-01)
6.1. Attachment and penetration of the uterine epithelium in the human: The present studies describe to our knowledge the only studies of human in vitro attachment of blastocysts to uterine epithelial monolayers. From these studies, using other mammalian species as
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