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About This Item

MDL number:
MFCD01867587
UNSPSC Code:
51111800
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biological source

mouse

recombinant

expressed in E. coli

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.05-0.1 mg per mL ED50 (For chemotaxis of BaF/3 hCXR1 cells)
6-12 mg per mL ED50 (for chemotaxis of Il-2 cultured lymphocytes)

mol wt

predicted mol wt ~10 kDa

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P47993

storage temp.

−20°C

Gene Information

mouse ... Xcl1(16963)

General description

Lymphotactin (XCL1) is generated by activated CD8+ T cells, Th1 (T helper)-polarized CD4+ T cells and NK (natural killer) cells. XCR1 (XC chemokine receptor 1) is a lymphotactin receptor.

Biochem/physiol Actions

Lymphotactin (Lptn), a member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues. Recombinant mouse lymphotactin has chemotactic activity for lymphocytes, NK cells, and mouse splenocytes, but not for monocytes or neutrophils.
Lymphotactin (XCL1) participates in the formation of lung granuloma. In humans, HIV (human immunodeficiency virus)-1 protein, Tat, upregulates XCL1 expression. Lymphotactin might be involved in the CNS (central nervous system) infiltration of T lymphocytes, leading to HIV-1-mediated neurological diseases.
Member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues; has chemotactic activity for lymphocytes, NK cells, and mouse splenocytes, but not for monocytes or neutrophils.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to chemoattract 3 week IL-2 cultured human lymphocytes and mouse BaF/3 cells transfected with hXCR1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
090K0940

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