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Merck
CN

L6795

LY311727

≥98% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):
C22H27N2O5P
CAS Number:
164083-84-5
Molecular Weight:
430.43
NACRES:
NA.77
PubChem Substance ID:
329817644
UNSPSC Code:
41106300
MDL number:
MFCD00943218

Key Documents

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InChI

1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)

SMILES string

CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc3ccccc3

InChI key

OPWQYOUZRHDKBR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

originator

Eli Lilly

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

LY311727 is an orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor.
Orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
041M4601V

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Shulin Hou et al.
Scientific reports, 7(1), 10815-10815 (2017-09-09)
Secreted phospholipases A
Deepti Dabral et al.
Cells, 8(4) (2019-04-17)
The fundamental molecular mechanism underlying the membrane merger steps of regulated exocytosis is highly conserved across cell types. Although involvement of Phospholipase A₂ (PLA₂) in regulated exocytosis has long been suggested, its function or that of its metabolites-a lyso-phospholipid and

Articles

Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

磷脂酶A2

磷脂酶A2（PLA2）代表的是一类可水解甘油磷脂的sn-2酯以产生脂肪酸和溶血磷脂的酶。目前已知的是，其中一些酶可在哺乳动物细胞中释放花生四烯酸以用于类花生酸的生物合成，因此PLA2抑制剂的开发引起了相当大的兴趣。基于氨基酸序列，现有超过12种不同的哺乳动物PLA2以及多种非哺乳动物的形式，它们被归类为具有多个亚组的14个组别。

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