L7009
Prolactin human
recombinant, expressed in E. coli, >97% (SDS-PAGE), lyophilized powder, suitable for cell culture
Synonym(s):
LTH, Lactogenic Hormone, Luteotropic Hormone, PRL
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About This Item
MDL number:
UNSPSC Code:
51111800
recombinant
expressed in E. coli
description
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
sterility
sterile; 0.2 μm filtered
Assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
predicted mol wt ~24 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PRL(5617)
Biochem/physiol Actions
Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Physical form
Lyophilized from a 0.2 μm filtered solution in 10 mM phosphate and 50 mM NaCl, pH 8.0.
Preparation Note
It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.
Analysis Note
Biological activity is measured in a cell proliferation assay using the rat lymphoma, Nb2-11.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Veronica Zaga-Clavellina et al.
American journal of obstetrics and gynecology, 211(1), 48-48 (2014-02-06)
To test the effect of prolactin (PRL) on expression of proinflammatory cytokines and matrix metallopeptidase 9 (MMP-9) in vitro. Tissue explants were incubated from 4 to 48 hours alone or in the presence of 500 ng/mL PRL, and mRNA expression
Katja Linher-Melville et al.
BMC cancer, 14, 415-415 (2014-06-11)
Liver kinase 1 (LKB1) is an important multi-tasking protein linked with metabolic signaling, also controlling polarity and cytoskeletal rearrangements in diverse cell types including cancer cells. Prolactin (PRL) and Signal transducer and activator of transcription (STAT) proteins have been associated
Tomohiro Yonezawa et al.
Cancer letters, 366(1), 84-92 (2015-06-23)
Controversy exists concerning the role of the long prolactin receptor (PRLR) in the progression of breast cancer. By targeting pre-mRNA splicing, we succeeded in knocking down only the long PRLR in vivo, leaving the short forms unaffected. Using two orthotopic
Alex Man Lai Wu et al.
American journal of physiology. Endocrinology and metabolism, 307(7), E596-E610 (2014-08-15)
The multidrug resistance efflux transporter ATP-binding cassette subfamily G member 2 (ABCG2) is not only overexpressed in certain drug-resistant cancers but is also highly expressed in the mammary gland during lactation, carrying xenobiotics and nutrients into milk. We sought to
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